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患者肢體的末端都會特別的肥大，主要的特徵是手指頭或腳指頭因為過度生長而變寬變大及粗曠的顏面外觀，還會有精神上的異常。青春期時生長激素過多，分泌生長激素的腦垂體腺瘤會在青春期前的病患產生巨人症，例如：身高比一般人的標準身高還要高出許多�

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